Cerebellar Cognitive Affective Syndrome Presented as Severe Borderline Personality Disorder

An increasing number of findings confirm the significance of cerebellum in affecting regulation and early learning. Most consistent findings refer to association of congenital vermis anomalies with deficits in nonmotor functions of cerebellum. In this paper we presented a young woman who was treated since sixteen years of age for polysubstance abuse, affective instability, and self-harming who was later diagnosed with borderline personality disorder. Since the neurological and neuropsychological reports pointed to signs of cerebellar dysfunction and dysexecutive syndrome, we performed magnetic resonance imaging of brain which demonstrated partially developed vermis and rhombencephalosynapsis. These findings match the description of cerebellar cognitive affective syndrome and show an overlap with clinical manifestations of borderline personality disorder

Electric cars: Are they solution to reduce CO2 emission?

Reducing CO2 emission is one of the major environmental challenges for transportation. One way to solve this problem is to replace old cars that use fossil fuels (petrol, diesel) with new electric cars. In this paper, the existing model for calculating well-to-wheels CO2 emission during the life cycle of the car (fossil fuel car and electric car) is upgraded. The developed model is used for comparing optimal lifetime and optimal car’s kilometers driven during a lifetime in the replacement process of a fossil fuel car with a new electric car. We find that reducing CO2 emission depends on the type of fossil fuel, and the weight of fossil fuel cars and electric cars. Changing petrol fossil fuel cars with lower weight electric cars have the greatest potential for reducing CO2 emission. However, the introduction of electric cars does not achieve a significant reduction of CO2 emission in countries where electricity is primarily produced in thermal power plants, i. e. in countries with a high emission factor of electricity production. [Projects of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR 36010, Grant no. TR 36022 and Grant no. TR 36027] Document type: Articl

DECLARE: Full Support for Loosely-Structured Processes

Traditional Workflow Management Systems (WFMSs) are not flexible enough to support loosely-structured pro- cesses. Furthermore, flexibility in contemporary WFMSs usually comes at a certain cost, such as lack of support for users, lack of methods for model analysis, lack of methods for analysis of past executions, etc. DECLARE is a proto- type of a WFMS that uses a constraint-based process mod- eling language for the development of declarative models describing loosely-structured processes. In this paper we show how DECLARE can support loosely-structured pro- cesses without sacrificing important WFMSs features like user support, model verification, analysis of past execu- tions, changing models at run-time, etc

Declarative Event-Based Workflow as Distributed Dynamic Condition Response Graphs

We present Dynamic Condition Response Graphs (DCR Graphs) as a declarative, event-based process model inspired by the workflow language employed by our industrial partner and conservatively generalizing prime event structures. A dynamic condition response graph is a directed graph with nodes representing the events that can happen and arrows representing four relations between events: condition, response, include, and exclude. Distributed DCR Graphs is then obtained by assigning roles to events and principals. We give a graphical notation inspired by related work by van der Aalst et al. We exemplify the use of distributed DCR Graphs on a simple workflow taken from a field study at a Danish hospital, pointing out their flexibility compared to imperative workflow models. Finally we provide a mapping from DCR Graphs to Buchi-automata.Comment: In Proceedings PLACES 2010, arXiv:1110.385

Constraint-based workflow management systems : shifting control to users

Many organizations use information technology to support various aspects of their business processes: the operational aspect, collaboration between employees, etc. Workow management systems aim at supporting the operational aspect of complex business processes by using process models to automate the ordering of activities (i.e., ow of work). The term `support' here relates to the ability of workow management systems to control the execution of business processes. Contemporary workow management systems lack exibility, i.e., the system controls in detail how employees should execute business processes. While work- ow management systems deal well with predictable business processes, they are not able to handle unforeseen situations, which occur often in real-life business processes. Although employees mostly have the knowledge and experience that enables them to deal with exceptional situations, they are not able to apply the right action because the system enforces the standard procedure of work. This often has various undesired consequences: work is done `outside' the system, work cannot be done in the appropriate way, dissatisfaction of employees, resistance towards the system, etc. As a result, workow management systems cannot be used properly if it is necessary that employees control the execution of business processes. This thesis proposes a new approach to workow management systems that can facilitate contemporary business processes in a better way by enabling a better balance between exibility and support. As opposed to traditional approaches which use procedural process models to explicitly (i.e., step-by-step) specify the execution procedure, the proposed approach aims at the specification of business processes using constraints, i.e., processes are modeled by rules that should be followed while executing business processes. Constraint-based models implicitly specify the execution procedure by means of constraints: any execution that does not violate constraints is possible. In addition to proposing a constrainbased approach, a concrete language for specification of constraints is given and the proof-of-concept prototype declare is described. On the one hand, constraint-based management systems are exible, which allows employees to deal with specific (e/g/. unpredicted) situations in the most adequate way. On the other hand, constraint-based management systems can support employees when it comes to aspects of business processes that are too complex for humans to handle. There are several ways in which constraintbased management systems can provide both exibility and support

Declarative and Procedural Approaches for Modelling Clinical Guidelines: Addressing Flexibility Issues

morpeleg¤ Abstract. Recent analysis of clinical Computer-Interpretable Guideline (CIG) modelling languages from the perspective of the control-flow patterns has revealed limited capabilities of these languages to provide flexibility for encoding and executing clinical guidelines. The concept of flexibility is of major importance in the medical-care domain since no guarantee can be given on predicting the state of patients at the point of care. In this paper, we illustrate how the flexibility of CIG modelling languages can be improved by describing clinical guidelines using a declarative approach. We propose a CIGDec language for modelling and enacting clinical guidelines. Keywords: Clinical guidelines, Computer-interpretable guidelines, flexibility, modelling languages, declarative model specification,temporal logic